Early intravenous tranexamic acid intervention reduces post-traumatic hidden blood loss in elderly patients with intertrochanteric fracture: a randomized controlled trial

Abstract Purpose Elderly patients with intertrochanteric fractures exhibit post-traumatic hidden blood loss (HBL). This study aimed to evaluate the efficacy and safety of reducing HBL via early intravenous (IV) tranexamic acid (TXA) intervention in elderly fracture. Methods A prospective randomized controlled was conducted 125 (age ≥ 65 years, injury time ≤ 6 h) who presented fracture from September 2018 2019. Patients TXA group ( n = 63) received 1 g IV at admission, whereas those normal saline (NS) 62) an equal volume saline. Hemoglobin (Hgb) hematocrit (Hct) were recorded admission (PTA) on days (PTDs) 1–3. calculated using Gross formula. Lower extremity venous ultrasound performed detect thrombosis. Results Hgb PTDs 2 3 statistically higher than NS group. Hct 1–3 significantly less compared Preoperative transfusion rate lower There no difference between two groups regard rates complications. Conclusion Early could reduce pre-operative without increasing risk